Description

The University of Connecticut Proteomics and Metabolomics Facility (UConn PMF, https://proteomics.uconn.edu) is hiring a Facilities Scientist 2 to assist the Facility Director with quantitative proteomics analysis using advanced mass spectrometry instrumentation and leading bioinformatics software. The PMF opened in 2017 as the University of Connecticut’s first proteomics-focused and full service mass spectrometry core facility, and is housed administratively within the Center for Open Research Resources and Equipment (https://core.uconn.edu). UConn PMF in Storrs has outstanding instrumentation (2 Waters TOFs, 2 Thermo Scientific Orbitraps, and a Bruker timsTOF HT) and is expanding its footprint to the UConn Health medical research campus (Farmington, CT) in Summer 2025 with a brand new Bruker timsTOF Ultra 2 mass spectrometer.  UConn PMF exists to provide fully customized analysis to more than 200 faculty across multiple UConn campuses and at other regional academic and industry research institutions. This position will be a full-time appointment and will provide a unique opportunity to work in a rapidly growing and highly productive core facility at a large research university currently ranked in the top 25 of all public universities in the U.S.

Requirements

MINIMUM QUALIFICATIONS

• Master’s degree in chemistry, biochemistry, analytical chemistry, or related field with at least 3 years of experience, OR Ph.D. degree in a similarly relevant field, with demonstrated experience implementing high resolution mass spectrometry for the analysis of proteins and peptides, and familiarity with operation, maintaining, and troubleshooting high resolution mass spectrometer and nanoflow ultra-high performance liquid chromatography systems.
• Publication history that demonstrates successful application of state-of-the-art mass spectrometry for label-free and/or label-based (e.g. Tandem Mass Tags, iTRAQ, SILAC) quantitative proteomics.
• Demonstrated experience using common proteomics software platforms for peptide/protein identification and quantification such as Spectronaut, MaxQuant/Andromeda, Proteome Discoverer, Byonic, and/or Scaffold Q+S.
• Demonstrated mastery of sample preparation techniques for downstream proteomics analysis such as in-gel/in-solution digestions, co-immunoprecipitations, and processing of whole cell lysates or tissue homogenates for bottom-up proteomics.
• Demonstrated clear and effective communication skills while communicating with researchers of varied scientific backgrounds, specifically regarding analytical techniques and informatics methods.
• Experience working in a highly collaborative environment that emphasizes comprehensive analysis and one-on-one consultations with researchers.

PREFERRED QUALIFICATIONS

• Experience with extensive collaborative projects or experience in a core facility setting.
• Experience using Bruker timsTOF instrumentation for low input proteomic analysis utilizing DDA-PASEF and DIA-PASEF acquisition methods.
• Experience with untargeted metabolomics workflows, including sample preparation and analysis using TOF instrumentation and small molecule identification using Progenesis QI, XCMS, and/or other programs.

APPLY ONLINE:

https://jobs.hr.uconn.edu/en-us/job/499108/facility-scientist-2