Sigma Xi, The Scientific Research Society's Career Center

Senior Research Associate Scientist - Protein Sciences

Bakx Therapeutics, Inc
Boston, Massachusetts, United States
5 days ago

Description

BAKX Therapeutics is developing safer and more effective drugs in the mitochondrial apoptosis pathway. We bring together biologists and clinicians with deep knowledge of apoptosis along with computational scientists, medicinal chemists & experienced drug developers for a uniquely integrated approach to discovering and developing drugs.

Position:
This is a laboratory-based position requiring a scientist with strong experience in protein sciences and assay development. This motivated and rigorous scientist will play a key role in protein expression, purification, and assay development within BAKX's protein science group. This work will support cutting-edge efforts to develop novel therapeutics in multiple drug discovery programs to address the unmet medical needs in oncology. This scientist will be a highly collaborative team player joining a world-class team of drug discovery scientists pioneering novel approaches targeting difficult to drug proteins using innovative computational and medicinal chemistry approaches.


Key Responsibilities:
• Protein expression, purification, and characterization with routine maintenance of mammalian
cell lines
• Protein purification using AKTA system with chromatographic techniques such as IMAC, IEC and
SEC etc.
• Routine molecular biology including construct design, bacterial cell transformation, DNA preps
and mammalian cell transfection
• Routine protein characterization including SDS-PAGE, analytical HPLC, Western Blotting, etc.
• Biochemical and biophysical assay development such as DSF, FP, TR-FRET, MST assays, etc.
• Evaluation and implementation of emerging technologies in protein production and assay
development
• Quantitative in vitro pharmacology experiments to evaluate small-molecule MOA and assess
potency
• Analysis and interpretation of experimental data
• Constructively and proactively suggest and implement problem-solving in the laboratory
• Timely documentation of experiments and associated data in laboratory notebooks to enable
reproduction of experiments and support IP filings
• Work as a team player, clearly communicate and share ideas and results in group meetings
• Provide general lab support as needed

“BAKX is an equal opportunity employer. All aspects of employment including recruiting, hiring, promotion, termination, compensation, and training, etc. will be based on merit, competence, performance, and business needs. We do not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.”



Requirements

Minimum Qualifications:
• M.S. in protein science or related scientific discipline with at least 3 years of pharma/biotech
industry experience
• Protein expression and purification experience including mammalian cell culture, protein
expression optimization, purification method development, and the ability to troubleshoot
scientific problems
• Hands-on experience in the operation of AKTA and HPLC system
• Protein characterization experience such as spectroscopy, protein assays, SDS-PAGE, Western
Blot etc.
• Understanding of and hands-on experience in in-vitro pharmacology experiments to assess small
molecule MOA and potency
• Experience with protein databases and electronic notebook is a plus
• Skilled in the use of analysis software such as GraphPad PRISM
• Rigorous and quantitative approach to laboratory experiments and analysis of data
• Ability to work with a sense of urgency under tight deadlines
• Excellent organizational and communication skills are required

Job Information

  • Job ID: 60571048
  • Location:
    Boston, Massachusetts, United States
  • Position Title: Senior Research Associate Scientist - Protein Sciences
  • Company Name For Job: Bakx Therapeutics, Inc
  • Job Function: Drug Discovery,
    Research
  • Job Type: Full-Time
  • Min Education: Master's Degree
  • Min Experience: 3-5 Years
  • Required Travel: 0-10%
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