Description
UbiquiTx is a stealth biotech company pioneering the next generation of targeted protein modulators. We are designing a novel class of therapeutics that potently and selectively modulate historically undruggable targets not currently addressable by small-molecule degraders, utilizing computationally-designed protein fusions that can both bind to a target of interest and tag it for targeted intracellular modulation.
UbiquiTx is seeking a highly motivated, creative and solutions-oriented Associate Scientist to join its therapeutic discovery team located in Cambridge, MA. As a member of an interdisciplinary team, this individual will support key aspects of biological assays, pre-clinical studies, platform, and research programs for the development of UbiquiTx’s programs and future pipeline product candidates. In this hands-on laboratory position, the successful candidate will contribute to the preclinical discovery, development and assessment of UbiquiTx’s novel platform. In particular, the applicant should have experience in mammalian cell culturing techniques, molecular biology, and in vitro assay development. The applicant is expected to have a robust experimental skill set, an eagerness for learning, and contribute to a strong culture of teamwork and collaboration in a fast-paced environment.
Primary responsibilities will include:
Molecular biology to generate mammalian and viral expression plasmids
Retroviral or lentiviral transduction of cell lines and expression validation, protein/antibody expression, qPCR, Flow Cytometry
Utilize a wide variety of molecular and cell biology techniques and present the data in a timely manner either as a scientific presentation or report
Generate, analyze, and interpret/communicate data
Plan and implement resolutions to technical issues and instrument troubleshooting when needed
Assist with general lab maintenance
Build and maintain relationships with vendors and assist with technical aspects of vendor negotiations
Actively contribute to a focused, team-oriented atmosphere providing assistance and/or guidance to colleagues when needed
Identify and implement scientific and logistical solutions in a multidisciplinary environment
Maintain high standards of laboratory safety
Requirements
The applicant should have experience in mammalian cell culturing techniques and in vitro assay development
The applicant is expected to have a robust experimental skill set, an eagerness for learning, and contribute to a strong culture of teamwork and collaboration in a fast-paced environment
MS/BS in Biology with a minimum of 2 years relevant experience
Ability to work independently and able to balance multiple tasks or projects
Diligent with details and timely execution and delivery of high-quality results
Background in basic or translational research, including but not limited to high throughput screening, cell-based assays, molecular biology and protein biochemistry
Attention to detail, organization skills, and rigorous experimental record keeping using an ELN system are critical
Collaborative, proactive and optimistic personality
Preferred/desired skills:
Experience working with primary cell lines or difficult cell line models generation of stable cell lines
Experience with AAV or Lenti/retroviral transduction
Nucleic acid quantitation by qPCR
Flow cytometry sample preparation and data analysis
Experience with molecular cloning techniques and site-directed mutagenesis
