Description

Legend Biotech is seeking a Sr. Associate Scientist/Associate Scientist as part of the R&D team based in Philadelphia, PA.

Role Overview

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of immunotherapy in the treatment of multiple myeloma.
This role supports early-stage development of engineered Lentiviral vectors by developing and executing analytical methods and testing strategies that enable candidate evaluation and selection. The position will generate critical, decision-driving data across exploratory phases and partner closely with cross-functional stakeholders, including Quality, to ensure analytical readiness as programs advance toward impactful gene therapies at Legend Biotech.

Key Responsibilities

• Perform Lentiviral vector (LVV) functional titration through transduction and flow cytometry.
• Quantify LVV genetic payload concentration via dPCR.
• Determine LVV protein concentration determination via ligand binding assays (ie. ELISA, MSD).
• Support method development, qualification and technology transfer across internal teams.
• Prepare and deliver analytical technical reports, data summaries and presentations.
• Enable strong across cross-functional execution through clear communication and data delivery across internal and partner teams.
• Maintain an organized, compliant laboratory environment to ensure consistency, traceability, and data integrity.
• Troubleshooting routine assay using data-driven root-cause approach, document results, and coordinate corrective actions with senior staff as needed.

Requirements

• BS degree with 3+ years relevant industry experience; MS degree with 1+ year or relevant industry experience; or PhD with +0 years of relevant industry experience in biochemistry, virology, molecular biology, cell&gene therapy, or a related field.
• Core technical foundation: Working knowledge of cell biology, biochemistry, and molecular biology concepts, including basic kinetic principles relevant to assay performance.
• Hands-on laboratory capability: Demonstrated ability to execute routine wet-lab experiments with attention to detail, consistency, and reproducibility.
• Data skills: Ability to analyze, interpret, and summarize experimental data: maintain accurate documentation and traceability.
• Communication: Clear written and verbal communication skills, including the ability to share results in reports, summaries, and presentations.
• Cross-functional mindset: Ability to work effectively with internal and cross-functional partners and respond to shifting priorities.
• Quality and compliance: Familiarity with good documentation practices and maintaining an organized lab environment to support data integrity and compliance expectations.
• Strong hands-on experience with LVV analytical assays, including cell transduction, flow cytometry-based functional titer, and genetic payload quantification (dPCR/qPCR).
• Experience with ligand-binding assays (e.g. ELISA, MSD) for protein quantification and/or residual impurity testing.
• Prior exposure to method development/optimization, qualification, and technology transfer in a developmental environment.
• Familiarity with data integrity expectations (traceability, controlled documentation) and partnering with QC teams.
• Ability to troubleshoot analytical methods using a data driven approach with appropriate escalation and documentation.
• Experience supporting lentiviral vector drug product characterization, including in vivo or translational studies.
• Comfortable working in a fast-paced environment, balancing short-term execution with longer-term assay/platform improvement.

#Li-JR1

#Li-Onsite

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.

Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.

Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.

EEO Statement

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.

For information related to our privacy policy, please review: Legend Biotech Privacy Policy.