Search for Jobs

0 Results
No jobs match your search. Try a different search or browse these great jobs below.
Mersana Therapeutics
Cambridge, Massachusetts, United States
21 hours ago
Montgomery County Police Department
Gaithersburg, MD, United States
22 hours ago
Lawrence Berkeley National Laboratory
Berkeley, CA, United States
22 hours ago
Kite Pharma
Santa Monica, CA, United States
23 hours ago
Moffitt Cancer Center
Tampa, FL, United States
23 hours ago
Albemarle Corporation
Kings Mountain, NC, United States
23 hours ago
Albemarle Corporation
Kings Mountain, NC, United States
1 day ago
Cargill
Milwaukee, WI, United States
1 day ago
Elektrofi Inc.
Boston, Massachusetts, United States
1 day ago
stratacuity
Burlington, Massachusetts, United States
1 day ago
stratacuity
Cambridge, Massachusetts, United States
1 day ago
Dartmouth-Hitchcock Health
Lebanon, NH, United States
1 day ago
Dartmouth-Hitchcock Health
Lebanon, NH, United States
1 day ago
Kelly Services
Greenville, NC, United States
1 day ago
Kelly Services
Cincinnati, OH, United States
1 day ago
Wells Fargo
Charlotte, NC, United States
1 day ago
Wells Fargo
Wilmington, DE, United States
1 day ago
British American Tobacco
Southampton, England, United Kingdom
1 day ago
British American Tobacco
Southampton, England, United Kingdom
1 day ago
Fluor Corporation
GREENVILLE, SC, United States
1 day ago
Accenture
IL, United States
1 day ago
Accenture
St. Louis, MO, United States
1 day ago
Lawrence Livermore National Laboratory
Livermore, CA, United States
1 day ago
Accenture
Arlington, VA, United States
1 day ago
1 - 25 Results of 2281
Mersana Therapeutics
Cambridge, Massachusetts, United States
21 hours ago

Description

Principal Scientist/Associate Director, Pharmacokinetics-Pharmacodynamics (PKPD)

What’s in it for you?

We are seeking a highly motivated scientist to join the Pharmacokinetics (PK) Group in the Department of Drug Metabolism and Pharmacokinetics (DMPK) at Mersana Therapeutics. In this role, you will lead the PK group and PK/Pharmacodynamics (PD) related efforts. You will have an opportunity to impact Mersana by influencing the PK related analysis and modeling strategies and providing PKPD insights based on integrated data. Additionally, you will form close partnerships with colleagues inside and outside DMPK such as Biotransformation and Bioanalysis (BA) scientists, biologists, chemists, toxicologists, clinical pharmacologists etc.  You will be an integral part of core non-clinical discovery and development project teams where you will actively contribute to definition of scientific objectives, communicate results, discuss significance of data, and propose next steps. This role reports to the Senior Director, DMPK.

How do you know if you’re the right fit?


You will have experience:

  • Performing hands-on PK analysis and modeling, interpret, integrate and report DMPK data and providing insights into PKPD
  • Designing, analyzing, and interpreting in vitro and in vivo non-clinical studies to understand PK and absorption, metabolism, distribution, and excretion (ADME) properties of ADC candidates
  • Developing and implementing mathematical PK/PD/Biomarker/Efficacy models to elucidate the quantitative PK/PD relationships in pre-clinical species
  • Establishing and implementing PKPD and physiology-based PK (PBPK) modeling strategies in integrating in vitro and in vivo data to gain in-depth understanding of the mechanism of action, cross-species translation, and human PK/dose projection in the non-clinical setting
  • Overseeing IND enabling studies in areas of PKPD and toxicokinetics, in collaboration with and support Toxicology, Biology, Clinical Pharmacology and other departments
  • Working with Clinical Pharmacology and/or CROs to assess the clinical potential for drug-to-drug interactions using PBPK modeling tools (e.g., SimCYP).
  • Authoring high quality regulatory documents including IND and BLA filings.
  • Potentially supervising junior scientists and/or associates

This position is best suited for PhD level candidates with 5+ years of experience or BS/MS candidates with 8+ years of experience in pharmacokinetics, pharmacology, pharmaceutical sciences or other related disciplines. 

Additional qualifications include:

  • Broad background knowledge in ADME with strong expertise in PK analysis and modeling (e.g., non-compartmental, compartmental, PBPK).
  • Basic programming language (e.g., R, Python) and in-depth understanding of PK principles and PKPD concepts
  • Hands-on modeling experience using Phoenix Winnonlin, Gastroplus, SimCYP, ADAPT and/or similar software
  • Experience with preparation of regulatory documents, such as IND, LBA, NDA, etc. desirable
  • Proven track record of scientific achievements and communication skills



The other stuff

Position is eligible for bonus, option awards and benefits including medical, dental and life insurance, 401(k) participation, vacation and paid holidays.

Successful candidate must be authorized to work in the United States.

Mersana Therapeutics, Inc. is an equal opportunity employer.



Job Information

  • Job ID: 60141874
  • Location:
    Cambridge, Massachusetts, United States
  • Position Title: Principal Scientist/Associate Director, Pharmacokinetics-Pharmacodynamics (PKPD)
  • Company Name For Job: Mersana Therapeutics
  • Job Function: Drug Discovery,
    Pharmacology,
    Pre-Clinical
  • Job Type: Full-Time

Please refer to the company's website or job descriptions to learn more about them.

View Full Profile

Jobs You May Like
Filters
Job Function
Industry
State