Description

At Insmed, every moment and every patient counts - and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you'll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person's contributions to meaningful progress. That commitment has earned us recognition as Science magazine's No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.

For patients, for each other, and for the future of science, we're in. Are you?

About the Role:
Insmed is seeking a highly experienced and creative biologist, virologist, or bioengineer to lead discovery and engineering initiatives aimed at developing next-generation gene therapies for rare diseases. The successful candidate will work within a cross-disciplinary team of experimental and computational scientists, performing wet-lab research to advance program objectives. This role is available at the Senior Scientist level.

What You'll Do:

• Lead biological engineering projects focused on development of next-generation viral vectors
• Independently design, optimize, and execute high-throughput molecular and cellular screening systems to identify and characterize novel viral capsids.
• Support viral vector projects, including transfection, transduction, viral titering, and sequencing-based characterization of viral genomes.
• Implement advanced molecular biology methods to design and build high diversity viral vector libraries
• Design, optimize, and execute molecular biology workflows, including DNA/RNA extraction, cloning and PCR/qPCR/ddPCR
• Prepare Next-Generation Sequencing (NGS) libraries (Illumina, Nanopore, PacBio) and perform quality measurements (qubit, tape station).
• Perform cell culture with mammalian cell lines and primary cells
• Design, conduct, and support in vivo studies
• Document protocols, write reports, and present findings to cross-disciplinary teams
• Contribute to laboratory operations, including training of junior staff and maintenance of high-quality research standards.

Who You Are:

• PhD in cell biology, virology, immunology, molecular biology, bioengineering, or related field with 4+ years of relevant industry or relevant Post Doc experience or MS with 8+ years of relevant hands-on experience. Direct report or small team management experience strongly preferred.
• Proven track record in method development, including experimental design, optimization, execution, and evaluation.
• Experience with viruses or viral vectors including AAV.
• Experience with viral transfection, transduction, ultracentrifugation purification (CsCl, iodixanol), genome titer (by qPCR, ddPCR, RT-qPCR, RT-ddPCR) and characterization.
• Experience with viral vector engineering (large library preparation and screening).
• Experience working with mammalian cell lines and primary cells.
• Hands-on in vivo model or study management experience.
• Experience with cell-based functional assays including but not limited to ELISpot, ICS, flow cytometry, antibody-neutralization assays, and potency assays.
• Strong written and oral communication skills.
• Applicants should be detail-oriented, highly organized, and able to multi-task with multiple projects.
• Strong analytical and problem-solving skills a must.

Nice to have (but not required):

• Background in advanced molecular biology methods including cloning and recombinant DNA technologies (DNA/RNA extraction, primer/probe design, PCR/qPCR/ddPCR, Gibson Assembly, Golden Gate etc.)
• Proficiency in NGS technologies (Illumina, Nanopore, PacBio), library preparation, and quality assessment (qubit, tape station).

• Experience with protein characterization methods, including but not limited to ELISA, SDS-PAGE, western blot, TFF, and affinity chromatography.

Where You'll Work

This role is based out of our New Hampshire office and requires full-time, in-person presence to support hands-on collaboration, access specialized equipment, and/or operational needs.

Travel Requirements

Minimal travel expected

Pay Range:
$127,000.00-165,500.00 Annual

Life at Insmed

At Insmed, you'll find a culture as human as our mission-intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.

Highlights of our U.S. offerings include:

• Comprehensive medical, dental, and vision coverage and mental health support, annual wellbeing reimbursement, and access to our Employee Assistance Program (EAP)
• Generous paid time off policies, fertility and family-forming benefits, caregiver support, and flexible work schedules with purposeful in-person collaboration
• 401(k) plan with a competitive company match, annual equity awards, and participation in our Employee Stock Purchase Plan (ESPP), and company-paid life and disability insurance
• Company Learning Institute providing access to LinkedIn Learning, skill building workshops, leadership programs, mentorship connections, and networking opportunities
• Employee resource groups, service and recognition programs, and meaningful opportunities to connect, volunteer, and give back

Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.

Current Insmed Employees: Please apply via the Jobs Hub in Workday.

Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at TotalRewards@insmed.com and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.