Description

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories' Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

We are looking for an energetic, innovative postdoctoral fellow with strong expertise in immunology, cell biology, or Neuroscience to join our Neuroscience team at the West Point, PA site. You'll become part of a highly collaborative research environment, working on a cross-functional project that bridges Neuroscience and Infectious Disease & Vaccines.

In this role you will:

• Design and execute mechanistic studies and develop relevant models to test hypotheses.
• Work closely with mentors and a multidisciplinary team to shape research plans, generate robust data, and produce novel, field-advancing insights in neuroimmunology.
• Launch and lead independent projects that investigate how adaptive immunity changes with aging and how these changes influence neurodegenerative disease.

If you are driven to translate curiosity into rigorously executed experiments and meaningful discoveries, this role offers the opportunity to make a significant impact at the interface of neuroscience and immunology.

Responsibilities include but are not limited to:

• Establish and optimize models of innate and adaptive immune modulation in pre-clinical species.
• Develop immunological assays to characterize innate and antigen-specific humoral and cellular immune responses.
• Perform neurodegenerative pathology analysis in animal models of disease using immunohistochemistry, western blot, Meso scale discovery assay et.al.
• Perform single cell assays including high-parameter flow cytometry and single cell omics profiling (e.g. single cell RNAseq and immune repertoire profiling).
• Data interpretation, manuscript and patent preparation, publication, and presentation.

Education Minimum Requirement:

• Ph.D. completed within 6 months of hire in Immunology, Cell biology, Neuroscience or related field.

Required Experience and Skills:

• Expertise in in vivo immunological response studies.
• Hands-on experience working with pre-clinical animal models and manipulating samples derived from these models.
• Hands-on experience and solid knowledge in aseptic techniques in tissue culture.
• Hands-on experience and solid knowledge in molecular biology and cell biology.
• Hands-on experience with in vitro assay development and troubleshooting.
• Experience in immunological assays (e.g. ELISA, ELISPOT, high-parameter flow cytometry, cell sorting, in vitro restimulation assays).
• Strong publication record and ability to design and execute experiments and interpret data.
• Excellent communication and collaboration skills.

Skills that would be a plus but not required:

• Experience in biochemistry/molecular biology assays (immunohistochemistry, western blot, Meso Scale Discovery assay et.al.)
• Familiarity or experience with single-cell omics assays and data analysis, in vitro restimulation assays.
• Familiarity or experience with Alzheimer's disease animal models
• Familiarity or experience with vaccine platforms.

postdoctoralopportunities

Required Skills:
Assay, Assay Development, Biochemical Assays, Blotting Techniques, Cell-Based Assays, Cell Biology, Cell Culture Techniques, Immunoassays, Immunochemistry, Immunofluorescence Microscopy, Immunology, In Vitro Assays, In Vivo Mouse Models, Molecular Biology, Neuroanatomy, Neurotrophins, Scientific Writing, Tissue Cultures

Preferred Skills:

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Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as "remote".

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Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles' Fair Chance Initiative for Hiring Ordinance

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Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:
Regular

Relocation:
Domestic

VISA Sponsorship:
Yes

Travel Requirements:
10%

Flexible Work Arrangements:
Not Applicable

Shift:
Not Indicated

Valid Driving License:
No

Hazardous Material(s):
N/A

Job Posting End Date:
12/18/2025
*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID:R370877