Description

Summary

Novello Therapeutics is seeking a highly motivated Scientist or Senior Scientist in Bioinformatics to play a key role in advancing our cryptic antigen discovery and validation platform. Reporting to the Director of Research, this individual will lead computational analyses of multi-omics datasets and build scalable pipelines to support antigen discovery, prioritization and validation. The ideal candidate is a hands-on computational biologist with deep experience in analysis of immunopeptidomics and/or mass spectrometry data, a strong interest in cancer immunotherapy, and thrives in an entrepreneurial environment.

Key Responsibilities

• Lead the design and implementation of computational workflows to identify and validate cancer-restricted cryptic peptides derived from the dark genome 
• Design, build, and maintain scalable computing architecture (cloud and/or on-premise high-performance computing clusters) optimized for high-throughput biological data processing
• Implement secure, organized, and cost-effective data storage and retrieval solutions for large datasets, maintaining compliance with data governance and security standards
• Identify, re-analyze and integrate large-scale public datasets, including: immunopeptidomics (mass spectrometry-derived HLA-peptide datasets), and other datasets
• Collaborate cross-functionally with immunology, protein engineering, and antibody discovery teams to support target discovery, validation, and indication selection 
• Stay current with emerging computational methods and data resources relevant to immunopeptidomics, proteogenomics, and cancer biology 
• Present findings to senior leadership, internal teams, and external collaborators, contribute to study reports, publications, and intellectual property

About Novello Therapeutics

Novello Therapeutics is unlocking the next frontier in cancer immunotherapy with cryptic antigendirected therapies—an innovative approach targeting cancerrestricted antigens derived from the dark proteome. As an emergent preclinical biotechnology company, Novello leverages the demonstrated efficacy of Tcell engagers (TCEs), a curated library of cancerrestricted cryptic peptides, and a proprietary, functionally credentialed suite of crypticantigen–directed TCRs. Novello’s differentiated platform is poised to generate a robust pipeline of cancerselective, nextgeneration therapeutics for malignancies with high unmet medical need.

Requirements

Qualifications

• Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related field (or equivalent industry experience)
• 1+ year (Scientist) or 3+ years (Senior Scientist) of relevant industry experience
• Strong experience with proteomics and/or immunopeptidomics workflows
• Experience analyzing mass spectrometry data (highly preferred)
• Experience integrating multi-omics data, including identification of and experience mining from existing datasets
• Familiar with understanding data analysis methods and potential for associated data artifacts
• Proficiency in programming (Python and/or R) and command-line tools
• Experience in cancer immunology or oncology antigen discovery preferred, familiarity with non-canonical ORFs
• Outstanding communication skills, both written and verbal
• Highly collaborative, team-oriented, able to thrive in a high-growth, fast-paced, early-stage environment